The Alexandra, 200-220 The Quays
MediaCityUK, Manchester M50 3SP

+44 (0) 161 877 8444

Face Treatment


Face Treatment


Introducing Nucleofill: The Anti-Aging Solution
Polynucleotides (PN) are gaining popularity as an anti-aging treatment due to its ease of administration and minimal downtime. It is a polynucleotide injectable bio-stimulant that promotes collagen and elastin production in the skin’s dermis, with its polynucleotide derived from salmon DNA.
As a biostimulator, Ameela is bio-compatible and encourages fibroblasts (collagen-producing cells) in the dermis to boost collagen and elastin production, resulting in tighter and lifted skin.
Polynucleotides, which are also used to create DNA, are bio-engineered to stimulate receptors on fibroblast cells in the skin’s dermis. This stimulation activates fibroblasts into type I collagen and elastin-producing myofibroblast cells, addressing the root cause of skin laxity and providing long-lasting, deep skin rejuvenation.
Antioxidant and Hydrating Effects
Polynucleotides also offers antioxidant benefits by acting as a free radical scavenger, protecting collagen fibers, rejuvenated skin, and the skin’s epidermis from further damage. Additionally, polynucleotides have a high affinity for water, allowing for deep and lasting hydration and hydro lifting of the skin, resulting in a firm and moisturized feel.
Who Can Benefit from Polynucleotides Treatment?
PN is suitable for those who:
  • Seek a long-lasting anti-aging solution
  • Have acne scars
  • Experience dry or dull skin
  • Are concerned about visible stretch marks
Expected Results from Polynucleotides
  • Firmer, more youthful-looking skin
  • Enhanced skin elasticity and reduced sagging
  • Increased collagen production for sustained skin firmness
  • Improvement in the appearance of fine lines and wrinkles
Polynucleotides vs. Fillers
Polynucleotides are not a filler; it consists of polynucleotide, while fillers are typically made of hyaluronic acid (HA). Fillers address volume loss issues associated with aging, while Polynucleotides focuses on rejuvenating and hydrating the skin. Polynucleotides can be used alongside dermal fillers for complementary effects.
Comparing Polynucleotides with Other Treatments
Polynucleotides vs. Profhilo: Profhilo contains pure concentrated hyaluronic acid, while Polynucleotides is a bio-stimulant gel made from polynucleotides. Profhilo provides excellent hydration, while Nucleofill may be more suitable for areas with thinner skin. Results for Polynucleotides typically last longer than Profhilo.
Polynucleotides vs. Rejuran: Both Polynucleotides and Rejuran are made from polynucleotide, but Polynucleotides has a higher concentration. They can be combined for better results, with Polynucleotides administered deeper into the skin and Rejuran more superficially.
Polynucleotides vs. Botox: Botox is a neurotoxic protein that causes muscle paralysis, making it more effective for dynamic wrinkles. Polynucleotides, with its bio-stimulant properties, can help with static or fine wrinkles.
Each syringe of Polynucleotides contains 2ml of the product.

At a glance

Expected Results

Enhanced skin elasticity

Treatment Time

30 minutes


Minimal to none


1-2 years


How often do I need treatment?Who

3-4 treatments every 2-4 weeks for the best results.

who is not suitable for Nucelofill?

Pregnant or breastfeeding individuals

Patients with underlying autoimmune diseases or coagulation disorders

How much Nucleofill is contained in each injection?

Each syringe of Ameela Polynucleotidescontains 2mls of the product

Prices from

Client Reviews

Jennie Murphy
Jennie Murphy
19 May 2024
Amazing 10/10 they were so supportive I had huge amounts of anxiety the whole time I was literally shaking but the loveliest woman ever held my hand and we chatted away and I love the results so far, id just like to thank them for being so professional they went super above and beyond the customer service is unreal!!!!
Abbey Bebbington
Abbey Bebbington
17 May 2024
I have been to see Amanda a few times now to help with the appearance of my acne scarring and redness. On my first appointment we had a very very thorough consultation which I really appreciated. I then went onto have halo and profractional laser, the aftercare was amazing and she was always on hand to answer any queries over message on her weekend! I have recently been for a checkup where I had more treatment in her own time just so I can get the best results possible. You're in extremely good hands at nassif med spa, everything is amazing from the second you walk through the door. I have had a lot of people curious about what I'm doing too. Thankyou!
Emma Fenlon
Emma Fenlon
27 April 2024
The Hydrafacial Platinum was absolutely fantastic, hands down the best facial I have ever had. My skin felt gorgeous afterwards and the whole experience was relaxing and rejuvenating. Nina was lovely, friendly and explained each stage, which was very reassuring. Amanda and Andi were so welcoming and professional. The clinic is beautifully clean and well presented. I will be back and have already recommended them and this particular treatment to friends and family. Thank you!
Ashley Spence
Ashley Spence
5 April 2024
Great experience throughout. Amanda was brilliant made me feel very relaxed and explained my treatment thoroughly. Looking forward to my next treatment.
Nikita Trehan
Nikita Trehan
29 March 2024
Always love coming here, everyone’s super friendly and such a relaxing atmosphere. They offer a range of incredible services & always going above & beyond.
The NewYou Skin Clinic
The NewYou Skin Clinic
18 March 2024
Amanda was absolutely superb . Very knowledgeable and reassuring. The clinic is beautiful . I will be returning in a month as advised . Very indepth consultation with no pressure at all . Highly recommend.
17 March 2024
An excellent clinic, highly recommended! I visited Nassif Medspa initially for BBL treatment, but soon progressed to Moxi and Hydrafacial treatments. Amanda is a consummate professional, who listened to my (difficult) in-depth journey, and made recommendations to help. My skin has never looked better! Her attention to detail is second-to-none; Amanda genuinely puts time, energy, and her soul into her work, and it really shows. Shout out to the lovely Andy and Nina too. A great clinic with awesome vibes. Big thumbs up! A++++++++++++++++++
Melinda Taylor
Melinda Taylor
8 March 2024
Very professional and know their stuff. Went for a consultation and would highly recommend
Deby Allison
Deby Allison
4 March 2024
Amazing Hydrafacial. The DPD delivery man said what have you done you look brand new.