The Alexandra, 200-220 The Quays
MediaCityUK, Manchester M50 3SP

+44 (0) 161 877 8444

Face Treatment


Face Treatment


Introducing Nucleofill: The Anti-Aging Solution
Polynucleotides (PN) are gaining popularity as an anti-aging treatment due to its ease of administration and minimal downtime. It is a polynucleotide injectable bio-stimulant that promotes collagen and elastin production in the skin’s dermis, with its polynucleotide derived from salmon DNA.
As a biostimulator, Ameela is bio-compatible and encourages fibroblasts (collagen-producing cells) in the dermis to boost collagen and elastin production, resulting in tighter and lifted skin.
Polynucleotides, which are also used to create DNA, are bio-engineered to stimulate receptors on fibroblast cells in the skin’s dermis. This stimulation activates fibroblasts into type I collagen and elastin-producing myofibroblast cells, addressing the root cause of skin laxity and providing long-lasting, deep skin rejuvenation.
Antioxidant and Hydrating Effects
Polynucleotides also offers antioxidant benefits by acting as a free radical scavenger, protecting collagen fibers, rejuvenated skin, and the skin’s epidermis from further damage. Additionally, polynucleotides have a high affinity for water, allowing for deep and lasting hydration and hydro lifting of the skin, resulting in a firm and moisturized feel.
Who Can Benefit from Polynucleotides Treatment?
PN is suitable for those who:
  • Seek a long-lasting anti-aging solution
  • Have acne scars
  • Experience dry or dull skin
  • Are concerned about visible stretch marks
Expected Results from Polynucleotides
  • Firmer, more youthful-looking skin
  • Enhanced skin elasticity and reduced sagging
  • Increased collagen production for sustained skin firmness
  • Improvement in the appearance of fine lines and wrinkles
Polynucleotides vs. Fillers
Polynucleotides are not a filler; it consists of polynucleotide, while fillers are typically made of hyaluronic acid (HA). Fillers address volume loss issues associated with aging, while Polynucleotides focuses on rejuvenating and hydrating the skin. Polynucleotides can be used alongside dermal fillers for complementary effects.
Comparing Polynucleotides with Other Treatments
Polynucleotides vs. Profhilo: Profhilo contains pure concentrated hyaluronic acid, while Polynucleotides is a bio-stimulant gel made from polynucleotides. Profhilo provides excellent hydration, while Nucleofill may be more suitable for areas with thinner skin. Results for Polynucleotides typically last longer than Profhilo.
Polynucleotides vs. Rejuran: Both Polynucleotides and Rejuran are made from polynucleotide, but Polynucleotides has a higher concentration. They can be combined for better results, with Polynucleotides administered deeper into the skin and Rejuran more superficially.
Polynucleotides vs. Botox: Botox is a neurotoxic protein that causes muscle paralysis, making it more effective for dynamic wrinkles. Polynucleotides, with its bio-stimulant properties, can help with static or fine wrinkles.
Each syringe of Polynucleotides contains 2ml of the product.

At a glance

Expected Results

Enhanced skin elasticity

Treatment Time

30 minutes


Minimal to none


1-2 years


How often do I need treatment?Who

3-4 treatments every 2-4 weeks for the best results.

who is not suitable for Nucelofill?

Pregnant or breastfeeding individuals

Patients with underlying autoimmune diseases or coagulation disorders

How much Nucleofill is contained in each injection?

Each syringe of Ameela Polynucleotidescontains 2mls of the product

Prices from

Client Reviews

Karen Fenlon
Karen Fenlon
We were made to feel very welcome as soon as we went through the door offered a drink while we waited The treatment was done in a very relaxed atmosphere and the Hydrafacial was explained as it was being done I left there feeling relaxed and my skin was rejuvenated I have rebooked and would recommend to anyone
Claire Brooker
Claire Brooker
Would not go anywhere, Jamie and Amanda are so attentive and just friendly. Really appreciate the care and attention! My lips look great and had loads of great comments, thanks!
Pili Paredes
Pili Paredes
I had my first BBL face treatment with Amanda, at Nassif medical spa and it went very well. I am looking forward to see how this treatment improves the skin on my face. Thank you very much Amanda.
siobhan walker
siobhan walker
I love going here, from the moment you enter you are greeted by lovely friendly staff, you even get a beautiful macaroon and lovely coffee or tea! The staff are knowledgeable, empathetic and want the best results for you. Amanda and Dr Jamie looked after me through every PRP treatments I’ve just had my third one! And both are highly, highly professional and so, so lovely and they really know what they are talking about. I couldn’t recommend Dr Nassif Medical Spa enough and I couldn’t recommend Dr Jamie and Amanda enough. I can’t wait for my next treatments ! Thank you so much guys see you in January ! :D
Bev Worrall
Bev Worrall
I had the best experience at NassifMD Medspa UK. The spa itself is beautiful and luxurious and in a great location on the Quays. On arrival I was met by Amanda and immediately I felt relaxed and at ease. My consultation with Dr Jamie was a joy ! His knowledge and experience is vast and nothing was too much trouble when faced with my endless questions and concerns. I was given several options of treatments and between us we decided on a course of action …. The results ? Well I’m absolutely thrilled ! I can’t wait for my next appointment.
michelle cunningham
michelle cunningham
I have had many services here and the service is not only impeccable the knowledge Amanda gives is fantastic. The Dr’s and nurses at Dr.Nassif’s medical spa are amazing. My hydrafacial was the best one I’ve ever had. I get PRP and profhilo, also the best. I’ve recently just had nucleofill for my under eyes & with what was left over the Dr noticed I had a slight outbreak of spots and administered the nucleofill there. 1 day post treatment my eyes look much better and my spots have started to clear up! The initiative and attention to detail on top of already an amazing treatment is what makes this clinic the best I’ve ever been too. I won’t go anywhere else. Thanks team for being so amazing! I wouldn’t trust my face with anyone else!
Kiran Patel
Kiran Patel
I’ve had 2 courses of Halo laser and my experience with Nassif Medical Spa has been amazing. Special thanks to Amanda who really goes the extra mile when caring for her clients. I’ve felt so supported by her throughout the entire experience from initial consultation through to aftercare and I throughly recommend her and this clinic! Amanda provides the compete package including well informed guidance, effective treatments and thoughtful aftercare. Her holistic approach will help you not only get the results you need but also work to then maintain them afterwards. Thanks again to her and the team! A well deserved 5/5 - I can’t fault them!
Christine Gallagher
Christine Gallagher
My 1st visit to this clinic , first impressions - such a beautiful well run , professional atmosphere. Amanda and staff helped put me at my ease and explained everything before my treatment. This included previous clients photos of before and after treatments and a thorough discussion of my needs, which put me at ease. My rosacea is much improved already after treatment and I look forward to my return for follow up and a second treatment.